ncRNA name | MALAT1 |
ncRNA Category | lncRNA |
ID | 378938 |
Ensembl | ENSG00000251562 |
Synonyms | HCN, LINC00047, MALAT-1, NCRNA00047, NEAT2, PRO1073, mascRNA |
Disease name | retinoblastoma (RB) |
Species | Homo sapiens |
Tissues/Cell_line | RB cell line Y79; RPE cell line ARPE-19 |
Methods | qRT-PCR, transfection, MTT assay, flow cytometry, migration and invasion assay, luciferase reporter assay, Western blot |
Expression pattern | up-regulated |
Functional description | The expression of MALAT1 was significantly higher in the Y79 cell line than in the ARPE-19 cell line. MALAT1 silence inhibited cell viability, migration, and invasion and promoted apoptosis in Y79 cells. miR-124 was upregulated by MALAT1 silence and hence was identified as a target of MALAT1. |
PubMed ID | 28550678 |
Year | 2018 |
Title | Knockdown of Long Noncoding RNA (lncRNA) Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Inhibits Proliferation, Migration, and Invasion and Promotes Apoptosis by Targeting miR-124 in Retinoblastoma. |
Drug-related ncRNA | NO |
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